POTENSI KANDUNGAN SENYAWA ANAPHYLATOXIN DALAM UMBI BIT MERAH (BETA VULGARIS L.) SEBAGAI JALUR KOMPLEMEN TERAPI INFLAMASI
Keywords:
Betalains, Beta vulgaris L, Anti-inflammatory, Anaphylatoxin, In silicoAbstract
Uncontrolled inflammation, often driven by the complement system's anaphylatoxins (C3a, C5a), is a key factor in many chronic diseases, prompting the search for novel anti-inflammatory agents from natural sources. This study aimed to predict the anti-inflammatory potential of bioactive compounds from beetroot (Beta vulgaris L.) through a computational approach. This research employed an in silico methodology, utilizing the PubChem database for compound identification and the Way2Drug PASS Online server to predict pharmacological activity. The predictive analysis revealed that betalains possess a high probability of acting as an anaphylatoxin receptor antagonist, with a Pa (Probability to be active) score of 0.860 and a Pi (Probability to be inactive) score of 0.006. These findings strongly suggest that betalains have significant potential as a natural anti-inflammatory agent by modulating the complement system pathway. This computational evidence provides a strong foundation for further experimental validation (in vitro and in vivo) to develop betalains as a therapeutic agent for inflammation-related diseases
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